|On 25 April 2016 the Administrative Board approved the Foundation’s Annual Report for 2015, which describes its activities during last year, as well as the financial statements for 2015. A total amount of Fr. 321,990.05 was paid out for research projects. The final reports on four projects were received and for the last time four new projects were approved. The Foundation will not be able to allot any new research grants because it is unlikely to receive funds to continue the activity of the Foundation alongside the planned 3R Competence Centre.|
Annual Report for 2015 | PDF version
3R-Info-Bulletin 56New EEG analysis models are being developed in order to precisely and topographically locate pathological processes as well as to improve our understanding of the importance and the function of electrical brain activities. Experiments are being carried out to measure the electrical activity in the brain both through the skin and through the cranium with a high resolution using laboratory animals. Such experiments fall into category 3 with regard to suffering among the animals used. Dr. Gonzales Andino is proposing a new EEG analysis model that would enable such measurement to be made on the surface of the head. The principle of the new EEG model has been successfully tested and the results have been published.
3R-Info Bulletin 56 | Project 119-10
|On 18. December 2015 the Administrative Board decided to cancel the call for grant applications in 2016. He regrets, that it is not possible to award new grants in 2016. The two sponsors of the 3R Research Foundation, namely the Federal Food Safety and Veterinary Office and Interpharma, will discontinue the support of the Foundation with a view to establishing a new 3R Competence Center.|
3R-Info-Bulletin 55Although basophils constitute only around 0.5% of the leukocyte population in the blood, they appear to play an important role in the body's allergic reactions as well as in modulating and regulating the immune response. Research relating to the function of these cells usually involves mouse basophils. Owing to the fact that their concentration in the blood is extremely small, large numbers of mice are required for isolating a minimal quantity of such cells from the blood. Dr. Kaufmann's research team succeeded in producing immortalised basophil progenitor cells with which a virtually unlimited quantity of mature basophils can be obtained in vitro.
3R-Info Bulletin 55 | Project 127-11
Validation of a novel cell-based approach to study thyroidal physiology: Reduction and/or replacement of experiments with rodents Rats are normally used to study the function of the thyroid and the role of its secreted hormones. Owing to the small size of the organ, such experiments involve the consumption of many animals. Using stem cells, it has recently become possible to generate three-dimensionally in vitro a functionally-competent model of the hormone-producing part of the thyroid, namely, the follicle. The project aims to validate this new in-vitro model using murine cells, and to ascertain whether various pharmacological and genetic manipulations influence its formation and signal transmission during hormonal steerage in a reproducible manner.
Dr. Gerasimos Sykiotis, Endocrinology, Diabetology and Metabolism Service, Vaud University Hospital, Lausanne, Switzerland
Combining computational modelling with in-vitro cellular responses in order to predict chemical impact on fish growth To examine the putatively negative side-effects of chemicals on the biological growth of fish and to determine the potentially poisonous impact of new substances that are intended for industrial and domestic use, hundreds of thousands of animals per year are legally subjected to experimental testing. The aim of this project is to develop a new computational model that is based upon toxicity data appertaining to cultured piscine cells. The comprehensive data-base that will be thereby derived will permit researchers in the future to conduct such testing computationally.
Prof. Kristin Schirmer, EAWAG, Dübendorf, Switzerland
Development of in-vitro three-dimensional multi-cellular culture models to study the role of heterotypic cellular interactions in colorectal cancer invasion The survival chances of patients with cancer of the colon or the rectum are poor, owing primarily to the capacity of the cancerous cells to invade the surrounding tissue and to metastasize. Relatively little research has been conducted to elucidate the mechanisms that underlie the invasive process. The murine models that are currently available for studying the attributes of colorectal cancerous cells are of only limited use. Prof. Rüegg's research team has developed a promising new in-vitro model which can be used to investigate the interactions of the colorectal cancerous with stromal cells during the process of invasive growth. This model will now be rendered more sophisticated by including other cells that are implicated in the process (vascular cells, immune cells, etc.), as well as organ-like modules that better simulate cancer-cell biology.
Prof. Curzio Rüegg, Department of Medicine, Chair of Pathology, University of Fribourg, Switzerland
An advanced in-vitro model of pulmonary inflammation based on a novel lung-on-chip technology Inflammatory changes in lung tissue often lead to serious breathing problems. The complex processes that occur at the air-blood barrier, and which impair the exchange of gases and the flow of blood and influence the breathing mechanism, are normally simulated in animal experiments. The aim of this project is to create a lung model on a chip that will enable researchers to investigate various basic functions of the lung under the influence of pathological agencies, such as a post-traumatic inflammation.
Prof. Olivier Guenat, ARTORG Centre, Lung Regeneration Tech, University of Berne, Switzerland
|On 26 May 2015 the Administrative Board approved the 2014 Annual Report on the Foundation's activities as well as the financial statements for 2014. A total of Fr. 401,912.85 was paid out for research projects. Four new projects were approved and eight final project reports were submitted. The Administrative Board and the Evaluation Committee were re-elected for a further 4 year period.|
Annual Report for 2014 | PDF version
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