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Donateurs de la Fondation Recherches 3R

Office fédéral de la sécurité alimentaire et des affaires vétérinaires, 3003 Bern

Interpharma, 4009 Bâle

- L' association des compagnies pharmaceutiques en Suisse

European National Consensus Platforms for 3R Alternatives in Animal Experimentation

ecopa - European Consensus Platform for Alternatives (3R-Methods) in Animal Experimentation

- Full members are: Austria, Belgium, Czech Republic, Denmark, Finland, France, Germany, Hungary, Italy, The Netherlands, Norway, Spain, Sweden, Switzerland, Associate members are: Ireland, Poland

National Consensus Platform Austria

- zet: Zentrum für Ersatz- und Ergänzungsmethoden zu Tierversuchen, Linz/Wien, Östereich.

National Consensus Platform Belgium

- La Plate-forme Belge des Méthodes Alternatives à l?expérimentation animale (BPAM) est un département scientifique de la Fondation Prince Laurent.Son acronyme est BPAM (Belgium Platform for Alternative Methods to Animal Testing)

National Consensus Platform Finland

- Fincopa: Finnish National Consensus Platform for Alternatives.

National Consensus Platform Germany

- set: Stiftung zur Förderung der Erforschung von Ersatz- und Ergänzungsmethoden zur Einschränkung von Tierversuchen

National Consensus Platform Italy

- IPAM: Italian Platform on Alternative Methods.

National Consensus Platform Netherland

- NCA: Netherlands Centre for Alternatives to Animal Use.

National Consensus Platform Norway

- Norecopa: National Platform for Alternatives.

National Consensus Platform Spain

- REMA: Red Española para el Desarrollo de Métodos Alternativos a la Experimentación Animal.

National Consensus Platform Sweden

- swecopa: Swedish Platform for the 3Rs alternatives to animal experiments.

National Consensus Platform Switzerland

- 3R Research Foundation Switzerland / Stiftung Forschung 3R / Fondation Recherches 3R

3Rs Initiatives,international institutions and projects of the European Commission (FP 6 and FP 7)


- an in-vitro Test Strategy for Predicting Human Acute Toxicity.


- in vitro neural tissue system for the replacement of transgenic animal with memory / learning deficiencies.


- Accelerating the transition to a toxicity pathway-based paradigm for chemical safety assessment through internationally co-ordinated research and technology development


- the main objective is to demonstrate how the use of modern simulation technique can lead to a more rational drug development process, improved treatment procedures, and a reduction in the needs for animal experiments.


- Case studies on the development and application of in silico techniques for environmental hazard and risk assessment.


- the aim of the project carcinoGENOMICS is to develop in vitro methods for assessing the carcinogenic potential of compounds.


- will provide reliable in vitro assays for use in screening chemicals for potential genotoxic and cytotoxic effects and will thus help to limit the amount of animal experimentation.

ECVAM - European Centre for the Validation of Alternative Methods

- assesses and validates, at the European level, advanced, alternatives to animal testing for regulatory toxicology. Includes a list of all validated methods and statements of the ESAC (ECVAM Scientific Advisory Board).


- Embryonic Stem cell-based Novel Alternative Testing Strategies

EPAA - European Partnership on Alternative Approaches to Animal Testing

- an unprecedented collaboration between the European Commission and major companies from seven industry sectors.


- aims to develop a drug safety database from the pharmaceutical industry legacy toxicology reports and public toxicology data; innovative in silico strategies and novel software tools to better predict the toxicological profiles of small molecules in early stages of the drug development pipeline.


- Development of 3D in vitro models of estrogen-reporter mouse tissues for the pharmaco-toxicological analysis of nuclear receptors-interacting compounds (NR-ICs)


- A forum for researchers and regulators to meet manufacturers of toxicology test methods, with the aim to facilitate or increase the number of commercial available in vitro/in silico methods.Includes the ForIn ViTox White Book.

IHCP/JRC - Institute for Health and Consumer Protection

- carries out research to improve the understanding of the hazards, exposure and risks posed by food contaminants, drugs,chemicals, products, services and systems.

NICEATM/ICCVAM - NTP Interagency Center for the Evaluation of Alternative Toxicological Methods and Interagency Coordinating Committee on the Validation of Alternative Methods in the US

- NICEATM administers the ICCVAM and provides scientific and operational support for ICCVAM-related activities; see also 'Test Method Evaluation'.


- Inovative Medicines Initiative.Europe's largest public-private initiative aiming to speed up the development of better and safer medicines for patients.


- reducing Animal Experimentation in Drug Testing by Human Cardiomyocyte In Vitro Models Derived from Embryonic Stem Cells.


- optimisation of liver and intestine in vitro model for pharmacokinetics and pharmacodynamics studies.


- Alternative testing strategies for the assessment of the toxicological profile of nanoparticles used in medical diagnostics.


- development of an interoperable predictive toxicology framework which may be used as an enabling platform for the creation of predictive toxicology applications.


- aims at developing a novel platform for anticipating liver and kidney chronic toxicity elicited by drugs and xenobiotics. The outcomes of this research is expected to contribute to animal experimentation replacement in the field of chronic toxicity assessment


- intends to explore the field of reproductive toxicity in order to reduce the number of animals used for its investigation.


- development of "in vitro" alternatives to animal tests currently used for the risk assessment of potential skin or lung sensitizers.


- highly parallel cell culture in nanodrops, a new format for high content toxicology cell based assays. Chips replace mice!.


- reducing Animal Experimentation in Preclinical Predictive Drug Testing by Human Hepatic In Vitro Models Derived from Embryonic Stem Cells.

Virtual Physiological Human Network of Excellence

- aims to help support and progress European research in biomedical modelling and simulation of the human body.

ZEBET - Zentralstelle zur Erfassung und Bewertung von Ersatz- und Ergänzungsmethoden zum Tierversuch

- Auskunftsstelle für die Bundesländer in Deutschland als für Ersatz- und Ergänzungsmethoden zu Tierversuchen (also in english).

Protéction des animaux et Législation

en Suisse

Loi fédérale sur la protection des animaux (LPA), Ordonnance sur la protection des animaux (OPAn)

Expériences sur animaux,rapports, directives éthiques,formulaires, statistiques sur les expériences sur animaux:

- information et directives

ASSM - Académie Suisse des Sciences Médicales

- Diagramme opérationnel pour la planification et l'éxécution d'expériences sur animaux

ASSM - Académie Suisse des Sciences Médicales

- Principes d'éthique et directives pour l'expérimentation animale (2005)

ASSM - Académie Suisse des Sciences Médicales

- Pesée éthique des intérêts lors d'expérimentations animales ? un modèle servant d'examen auto-critique

à l'étranger

Directive 2010/63/EU

- du Parlement européen et du Conseil du 22 septembre 2010 relative à la protection des animaux utilisés à des fins scientifiques

EUR-Lex Access to European Union law

- Section 15.40 Protection of animals

Europarat: Europäisches Übereinkommen zum Schutz der für Versuche und andere wissenschaftliche Zwecke verwendeten Wirbeltiere

- SEV Nr.: 123

Amtsblatt der Europäischen Union, L 197

- Europäische Leitlinien vom 18.Juni 2007 für die Unterbringung und Pflege von Tieren, die für Versuche und andere wissenschaftliche Zwecke verwendet werden

Europarat: Änderungsprotokoll zu dem Europäischen Übereinkommen zum Schutz der für Versuche und andere wissenschaftliche Zwecke verwendeten Wirbeltiere

- SEV Nr.: 170


Council of Europe: European Convention for the Protection of Vertebrate Animals used for Experimental and other Scientific Purposes

- CETS no.: 123

Official Journal of the European Union, L 197

- European guidelines of 18 June 2007 for the accommodation and care of animals used for experimental and other scientific purposes

Council of Europe: Protocol of Amendement to the European Convention for the Protection of Vertebrate Animals used for Experimental and other Scientific Purposes

- CETS no.: 170

Germany- Animal Welfare act, Main Features

- overview in english provided by Michigan State University, College of Law

France - Animal Protection Legislation and Animal Research

- an english summary of the legislation provided by EBRA (Eropean Biomedical Research Association)

Germany - Animal Protection Legislation and Animal Research

- an english summary of the legislation provided by EBRA (Eropean Biomedical Research Association)

Netherland - The Dutch Experiments on Animal Act

- english translation

Norway -Norwegian Animal Welfare Act

- New Animal Welfare Act entered into force on 1 January 2010

UK - Home Office, Science, Research and Statistics

- Animals in Scientific Procedures; includes Legislation, Animal Welfare, Application forms

Sweden - The Animal Welfare Act and Ordinance

- extracts translated into english

Legislation Worldwide

- Legislations, Regulations, Guidelines Worldwide on the internet; a collection made by FRAME

Laboratory Animal Husbandry and Laboratory Animal Care and Welfare

AAALAC - Association for Assessment and Accreditation of Laboratory Care International

-a private, nonprofit organization that promotes the humane treatment of animals in science through voluntary accreditation and assessment programs

AALAS - American Association for Laboratory Animal Science

- advances responsible care and use of laboratory animals to benefit people and animals

ANZCCART - Australian and New Zealand Council for the Care of Animals in Research and Teaching

- information for animal carers, animal ethics committee members and scientists as well as other interested parties.

AWIC - Animal Welfare Information Center; U.S. Department of Agriculture and National Acricultural Library

- provide information for improved animal care and use in research, testing, teaching, and exhibition.

CCAC - Canadian Council on Animal care

- national organization responsible for setting and maintaining standards for the care and use of animals in science in Canada; aussi en français.

ECLAM - European College of Laboratory Animal Medicine

- the veterinary college within Europe for the speciality of laboratory animal medicine, and like other veterinary speciality colleges is overseen by the European Board of Veterinary Specialisation.

ESLAV - European Society of Laboratory Animal Veterinarianse

- gives veterinarians a forum to discuss issues which concern them, in the field of laboratory animal science, in general and in Europe specifically.

efE - ECLAM/ESLAV Foundation

- Foundation for research directed into refinements in the welfare of laboratory animals.

FELASA - Federation of European Laboratory Animal Science Associations

- coordinates education and training in Europe; publishes recommendations, policy documents and statements; organizes courses and meetings.

Finnish National Laboratory Animal Center

- belongs to the University of Kuopio: Research, Health Monitoring, Index of Laboratory Animals.

ICLAS - International Council for Laboratory Animal Science

- an international scientific organization dedicated to advancing human and animal health by promoting the ethical care and use of laboratory animals in research worldwide.

IGN - Internationale Gesellschaft für Nutztierhaltung

- promotes the proper housing, breeding, nutrition and treatment of farm animals on a scientific basis; in german and english.

IVIS - International Veterinary Information Service

- a not-for-profit organization to provide information to veterinarians, veterinary students and animal health professionals using internet technology (free registration, with password).

GV-SOLAS - Gesellschaft für Versuchstierkunde, Deutschland - Society for Laboratory Animal Science, Germany

- Förderung der Wissenschaft auf dem Gebiet der Versuchstierkunde. Die Gesellschaft versteht sich als Gesprächspartner für den Gesetzgeber und die Öffentlichkeit.

NORINA - The Norwegian Reference Centre for Laboratory Animal Science and Alternatives

- database containing information on over 3,800 audiovisual aids that may be used as alternatives or supplements to the use of animals in teaching and training, including dissection alternatives, at all levels from junior school to University.

SGV - Swiss Laboratory Animal Science Association

- founded in 1987; its aim is the promotion of laboratory animal science and the furthering of animal protection and ethical considerations in animal experiments.

UFAW - Universities Federation for Animal Welfare

- an independent registered charity that works to develop and promote improvements in the welfare of all animals through scientific and educational activity worldwide.

USDA/APHIS - Animal and Plant Health Inspection Services

- administers the Animal Welfare Act in the USA

Research Animal Resources - University of Minnesota

- provides resources for the care, health and well-being of animals used for research and education at the University of Minnesota.

3R related Organisations and Research Foundations in addition to the European National Consensus Platforms for 3R Alternatives

AltTox - Non-animal Methods for Toxicity Testing

- a website dedicated to advancing non-animal methods of toxicity testing through online discussion and information exchange

Altweb - Alternatives to Animal Testing on the web

- a gateway to news, information, discussion, and resources from the field of alternatives to animal testing. Created and maintained by the Center for Alternatives to Animal Testing at The Johns Hopkins Univesity, Baltimore.


- support research projects which further the replacement or at least the reduction of animal experiments (also in german).

Biographics Laboratory 3R - Computational Alternatives to Animal Testing

- a non-profit research organization dedicated to the reduction and replacement of animal tests by computational methods.

CAAT - Center For Alternatives To Animal Testing - The Johns Hopkins University, Baltimore

- provide a variety of resources, including grants for scientists developing non-animal methods workshops on alternative methods, books, newsletters, and other publications. Responsible for the Altweb site.

Doerenkamp-Zbinden Foundation

- supports animal free research projects, provides the DZ-prize bestowed with 25.000 CHF and establish and finances 3R professorships and Centers worldwide (also in german).

ecopa - European Consensus Platform on Alternative Methods

- represents the pan-European umbrella organisation of national consensus platforms (NCP) consisting of those four parties (animal welfare organisations, industries, governmental institutions and academia) interested in fostering research, development and implementation of 3R alternatives to animal experiments.

Erna-Graff-Stiftung für Tierschutz

- provies comprehensive and profound teaching material which is applicable for almost all school subjects (also in german).

FoA - Focus on Alternatives

- a committee of representatives from British non-profit organisations which fund the development, or promote the acceptance, of methods that replace the use of laboratory animals in research, education and testing. Includes an overview of serum-free media for cell culture.

Forschung fuer Leben

- information for teachers and journalists about the goals, significance and results in the area of bio-medical research (in german).

FRAME - Fund for the Replacement of Animals in Medical Experiments

FRAME supports efforts to reduce the numbers of animals used, through better experimental design and data analysis and to refine procedures.

HSUS - Humane Society of the United States

- seeks a truly humane society in which animals are respected for their intrinsic value, and where the human-animal bond is strong.

IFER - The International Foundation for Ethical Research

- supports the development and implementation of scientifically valid alternatives that refine, reduce or replacce the use of live animals in research, product testing and classroom education.

IIVS - Institute for In Vitro Sciences

- a non-profit science-based organization dedicated to the advancement of alternative testing methods.

The Lord Dowding Fund Humanity in Research

- funds the development of alternatives to replace animal experiments in medical research.

NC3Rs - National Centre for the Replacement, Refinement and Reduction of Animals in Research, UK

- provides a focus for the promotion development and implementation of the 3Rs in animal research. Funded by the MRC, BBSRC, Wellcome Trust, ABPI and the Home Office.

NCA - The Netherlands Centre for Alternatives to Animal Use

- The NCA stimulates the development, validation and application of alternatives to animal experiments in the Netherlands (including Newsletters).

Stiftung für das Tier im Recht

- unterstützt und fördert national und international die Weiterentwicklung von Recht und Ethik zum Schutz der Tiere und in der Beziehung zwischen Mensch und Tier.

The Swedish Fund for Research Without Animal Experiments

- Provides funds the development of alternatives to experiments on live animals, specifically for painful animal experiments.

UCCAA - University of California Davis, Center for Animal Alternatives

- Information on alternative methods in science and education.

3R Banques de données et Journal

ALTEX - Alternatives to Animal Experimentation

- A quarterly journal for new paths in biomedical science; official organ of CAAT (Center for Alternatives to Animal Testing, Johns Hopkins University, Baltimore), EUSAAT (European Society for Alternatives to Animal Testing, Vienna), t4 (Transatlantic Think Tank of Toxicology, Baltimore, Constance, Utrecht). (in english and german)

ALTBIB - Bibliography on Alternatives to the Use of Live Vertebrates in Biomedical Research and Testing

- provided by the U.S. National Library of Medicine, includes citations from published articles, books, book chapters, and technical reports from 1980 to 2000.

ATLA - Alternatives to Laboratory Animals

- an international, peer-reviewed scientific journal, publishing articles on the latest research relating to the development, validation, introduction and use of alternatives to laboratory animals.

ATCC - American Type Culture Collection

- ATCC is a private, nonprofit biological resource center (BRC) and research organization whose mission focuses on the acquisition, authentication, production, preservation, development and distribution of standard reference microorganisms, cell lines and other materials for research in the life sciences.

DB ALM - ECVAM database service on alternative methods to animal experimentation

- In Vitro Methods-INVITTOX protocols-Formal validation studies-Test compounds and test results-Bibliographic references.

easypresto - Document Ordering Centre University of Bern, Switzerland

- The easypresto Document Ordering Center delivers copies in PDF format or, with a surcharge, copies on paper, of articles cited in databases or in literature.

ExPASy - Expert Protein Analysis System

- The ExPASy (Expert Protein Analysis System) proteomics server of the Swiss Institute of Bioinformatics (SIB) is dedicated to the analysis of protein sequences and structures as well as 2-D PAGE.

go3R - semantic search to avoid animal experiments

- ontology-based literature search; keywords are submitted to PubMed and the resulting abstracts are classified using Gene Ontology and Medical Subject Headings (MeSH).

PubMed, Medline, U.S. National Library of Medicine

- PubMed, a service of the National Library of Medicine, provides access to over 11 million MEDLINE citations back to the mid-1960's and additional life science journals.

OECD Section Health - Organisation for the Economic Cooperation and Development

- includes themes like: Chemical Safety, Environmental and Health.

OECD - Section Environment - Chemical Safety-Chemicals Testing

- Guidelines for the testing of chemicals No 401-486.

SEFREC - Interactive database about serum free medias and cell lines

- interactive database simplifies the search for current serum free cells and serum free medias.

SWITCH - Swiss Libraries

TOXNET- Toxicology Data Network

- A cluster of databases on toxicology, hazardous chemicals and related areas

ZEBET - Datenbank über Alternativen zu Tierversuchen im Internet (AnimAlt-ZEBET)

- Datenbank mit bewerteten Informationen über Alternativmethoden; also in english.

Continuing Education, Educational Resources


- an interactive short course on experimental design for research scientists working with laboratory animals.

AHWLA - Assessing the Health and Welfare of Laboratory Animals

- tutorials from the University of Newcastle about: Basic assessment of Laboratory Animals Health and Welfare and Recognising post-operative pain in animals.

CAATalyst: A Student Newsletter

- introduce the concepts of alternatives to animal testing to middle school students and their teachers.

eurca - European Resource Centre for Alternatives in Higher Education

- actively promotes the use of alternatives to using animals in higher education (HE).

InterNICHE - International Network for Humane Education

- Support progressive science teaching and the replacement of animal experiments by working with teachers to introduce alternatives.

Institut für Labortierkunde Universität Zürich, Switzerland

VIAVET - Derpartment of Laboratory Animal Sciences, Faculty of Veterinary Medicine, TD Utrecht, The Netherlands

- Information on post-graduate and international courses on Laboratory Animal Sciences (in dutch and english).

In Vitro Research in Life Sciences, Societies

ETCS - The European Tissue Culture Society (ETCS)

- aims to support progress in Cell and Molecular Biology and in related research areas where in vitro systems are applied.

IVTIP - In Vitro Testing Industrial Platform

- Forum of European compagnies with an active interest in in vitro testing in research, development and regulatory testing.

ecetoc - European Centre for Ecotoxicology and Toxicology of Chemicals

- a scientific, non-profit making, non-commercial association. Its objective is to identify, evaluate and through such knowledge help industry minimise, any potentially adverse effects on health and the environment that may arise from the manufacture and use of chemicals.

ESTIV - European Society of Toxicology In Vitro

- ESTIV promotes in vitro toxicology, both scientifically and educationally, in all countries of Europe.

Fonds National de la Recherche Suisse, Berne

- available in German, French, Italian and English; includes funding opportunities, project database, calls, research programmes

SIVB - Society for In Vitro Biology

- fosters the exchange of knowledge of in vitro biology of cells, tissues and organs from both plant and animals (including humans). The focus is on biological research, development, and applications of significance to science and society.

STCS - The Swiss Tissue Culture Society (STCS)

- aims to support progress in Cell and Molecular Biology and in related research areas where in vitro systems are applied.

Protéction des animaux

aavs - American Anti-Vivisection Society

- provides information and grants to scientists and educators to replace animal use in laboratories.

Deutscher Tierschutzbund

- Europas größte Tier- und Naturschutzdachorganisation

EUROGROUP - European Federation of Animal Protection Organisations

- Eurogroup works towards the introduction, implementation and enforcement of legislation on the protection of animals in the European Union.

Société protectrice des animaux France

STS - Schweizer Tierschutz

- Mitglied der "World Society for the Protection of Animals" und von "EuroGroup".

TASSO - Europäischer Tierschutz im Internet

- Europas größter Knotenpunkt im Internet für Tierschutz-Sites.

WSPA - World Society for the Protection of Animals

- aims to promote the protection of animals, to prevent cruelty to animals, and to relieve animal suffering.

Zürcher Tierschutz, Zürich, Switzerland

Vier Pfoten - Tierschutzverein

- eine international tätige, gemeinnützige Stiftung für Tierschutz.

In Vitro Research in Life Sciences, commercial companies

axioGENESIS - Biotechnology company located in Cologne, Germany

- develops novel assays that use differentiated embryonic stem cell (ES) and induced pluripotent stem cell (iPS) derived cell types, the current focus is on cardiomyoctyes

CARDAM - Centre for Advanced Research and Deveopment on Alternative Methods

- devotes itself to replace and reduce the use of animals in safety testing

Cellular Dynamics,international, USA

- producer of fully functional human cells derived from induced pluripotent stem (iPS)cells, provides industrialized quantities of terminally differentiated human cells

InVitro International, Irvine, CA, USA

- provider of non-animal testing methods (e.g. Corrositex, Irritection Assay System)

Celsis - In Vitro Technologies, USA

- in vitro testing services and products for studying chemical-biological interactions in vitro

Epithelix, Switzerland

- In Vitro Solutions for Respiratory Diseases and Chemical Testing, provider of reconstituted human in vitro tissues with long shelf-life

InSphero, Switzerland

- supplier of organotypic, biological microtissues (organotypic 3D microtissue spheroids) for biomimetic drug testing

SkinEthic Laboratories

- Biologically Standardized Human Tissue Models For Industrial In Vitro Testing

GenPharmTox, Gemany

- includes V79 Cell Battery which depicts the metabolism of humans and other species in genetically modified cells.

MatTek Corporation, MA, USA

- producer of ready-to-use in vitro 3-D human epithelial tissue equivalents.

MB Research Laboratories, Spinnerstown, PA, USA

- use and development of alternative and in vitro toxicology methods

VitroCell, Gutach, Germany

- In vitro Toxicology using human cells