3R Info Bulletins

Fish Acute Toxicity Test: The number of animals can be reduced

The blood-brain barrier in a dish: a new multicellular in vitro model

A novel in-vitro cell model of the human airway epithelium

Refined ex-vivo rodent heart model reduces in vivo experimentation

Detection of Pain in Laboratory Animals via Gene Expression?

An in-vitro system for detecting the health effects of inhaled particles and gases

Bioconcentration of chemicals in fish can be assessed in vitro

Host pathogen interactions can be studied in amoebae instead of animals

From blood to brain and vice versa: Transport Processes in Choroid Plexus can be studied in vitro

Exploring natural anticoagulation by endothelial cells: A novel in vitro model

Predicting drug hypersensitivity by in vitro tests

Non-Invasive Methods: Investigation of Airways Diseases by MRI in Rats

Improvement of Pain Therapy in Laboratory Mice

Environmental enrichment does not disrupt standardization

Computer-based quantification of (adverse) effects triggered by drugs and chemicals

Bone metabolism and bone-biomaterial interactions can be studied ex vivo

The tick blood meal: From a living animal or from a silicone membrane?

Immune cells in the liver : The generation and use of a mouse Kupffer cell line

Formation of new blood vessels in the heart can be studied in cell cultures

Generation of parasite cysts in cultured cells instead of living animals.

Simulation of stroke related damage in cultured human nerve cells.

Environmental enrichment does not affect the variability of animal experimentation data in the Light/Dark test.

Identification of new human skin irritation markers for tests with human skin reconstructs

Animal-free screening of biological materials for their contamination by rodent viruses

Phenotype Characterisation and Welfare Assessment of Transgenic Mice

Prevention of adverse effects in pigs after vaccination

Fever in the test tube - towards a human(e) pyrogen test

Housing and husbandry conditions affect stereotypic behaviour in laboratory gerbils

Aggregating brain cell cultures: Investigation of stroke related brain damage

Transgenic protozoa as an alternative to transgenic animals

Identification of neurotoxic chemicals in cell cultures

Leishmaniasis: Development of an in vitro assay for drug screening

Immunization of laboratory animals

Ten years Foundation Research 3R

Permanent fish cell cultures as novel tools in environmental toxicology

Regulation of digestion in cell culture

The three 'R's of Russell & Burch, 1959

Call for 3R-Research Proposals

Human recombinant antibodies

Predicting human drug metabolism

Gerhard Zbinden and 3R

mAbs without mice?

Foundation Research 3R

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3R-INFO-BULLETIN 1 - June 1994

FOUNDATION RESEARCH 3R promotes research on alternative methods for animal experimentation according to the principles of 3R: Reduction, Refinement and Replacement.
This bulletin describes the situation of the 3R Research Foundation in 1994. For updated information please contact the chapter News, Information, Guidelines and Projects on this Website. Thank you.

FOUNDATION RESEARCH 3R is funded in equal parts by contributions from INTERPHARMA Switzerland and the Swiss Federal Veterinary Office.

Both partners promote the principles of 3R by supporting research in academic, industrial and public research facilities in Switzerland.

The Foundation supports projects addressing replacement and improvements in animal experimentation. Special emphasis is placed on alleviation of pain and discomfort to experimental animals.

42 research projects have been initiated since the Foundation was established in 1987.

FOUNDATION RESEARCH 3R is named in German "STIFTUNG FORSCHUNG 3R - Vermindern, Verbessern und Vermeiden von Tierversuchen" and in French "Fondation Recherches 3R - Réduction, Réforme et Remplacement des expériences sur animaux". The Foundation is registered in Münsingen, Canton of Berne, Switzerland.

The executive bodies of the Foundation are the Foundation Board (nine members) and the controlling and supervising bodies.

The Foundation is managed by the Foundation Board. Five scientific experts review submitted projects.

Four groups are represented in the Foundation Board: Industry (2 delegates), Animal Welfare (2 delegates), the Federal Veterinary Office of the Swiss Government (2 delegates), and the Swiss Parliamentarian Group for animal experimentation (3 deputies).

Foundation Board :

Ms Susi Eppenberger, chairwoman, Nesslau
Hugo Wick, Dr., vice-chairman, Basel
Peter Bossard, Dr., Horw
Heinz Durrer, Prof., Basel
Paul Herrling, Dr., Basel
Ulrich Kihm, Prof., Berne
Hans Meier, Glattfelden
Andreas Steiger, Dr., Berne
Hans-Rudolf Widmer, Dr., Basel

Secretary:

Ernst Diener, lawyer, Berne

Board of experts:

Heinz Durrer, Prof., Basel
Paul Herrling, Dr., Basel
Beda M. Stadler, Prof., Berne
Andreas Steiger, Dr., Berne
Ms Regula Vogel, Dr., Berne

Controlling and supervising bodies:

KPMG Fides Peat, audit, Berne
Federal Department of Home Affairs

Statutes:

Stiftungsurkunde vom 13. Februar 1987
Reglement vom 15. Mai 1987
Richtlinien für die Gewährung von Forschungsbeiträgen vom 15. Mai 1987

3R principles are promoted by selecting projects according to research priorities. During the funding period 1991 to 1994 the following research areas were encouraged:
3R and pharmacodynamics in the nervous system.
3R and pharmacodynamics of inflammation and analgesia.
3R and diagnostics of infectious diseases.
3R and immunology - production of mono- and polyclonal antibodies.

From 1993 to 1997 the following financing is scheduled, consisting of contributions to the Foundation, the amounts free in favour of new projects and allocations for running projects:

In view of the numerous successful applications started from 1991 to 1993, the Foundation will now concentrate on monitoring, evaluation and publishing of the ongoing projects.

The next dates to submit research proposals for 3R-Funding are:
1st of March 1995 and
1st of October 1995.

Last modified 2008/01/30