Stiftung Forschung 3R - Startseite
3R-Methoden


 

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Projektverzeichnis

Organs and Tissues

CORNEA

Organ culture assay as a replacement for the Draize test (April 2011)
Interaction of chemicals and pharmaceuticals with the eye can be investigated using an organ culture in vitro assay based on rabbit corneas obtained from abattoir waste. Full metabolic function is maintained over a culturing period of up to 21 day enabling observation of recovery after chemical or mechanical trauma and undesired side effects during pharmaceutical treatment without the need for animal experiments. More...
 

DENDRITIC CELLS

3D model of human epithelial airway barrier (Juni 2010)
Particle-lung cell interactions can be investigated in a triple cell culture in vitro model of the human airway wall. It is possible to analyze the cellular interplay and response of epithelial cells, human blood monocyte derived macrophages and dendritic cells after exposure to particles. More...
 

EPITHELIA

3D model of human epithelial airway barrier (Juni 2010)
Particle-lung cell interactions can be investigated in a triple cell culture in vitro model of the human airway wall. It is possible to analyze the cellular interplay and response of epithelial cells, human blood monocyte derived macrophages and dendritic cells after exposure to particles. More...
 

EYE

Organ culture assay as a replacement for the Draize test (April 2011)
Interaction of chemicals and pharmaceuticals with the eye can be investigated using an organ culture in vitro assay based on rabbit corneas obtained from abattoir waste. Full metabolic function is maintained over a culturing period of up to 21 day enabling observation of recovery after chemical or mechanical trauma and undesired side effects during pharmaceutical treatment without the need for animal experiments. More...
 

LUNG

3D model of human epithelial airway barrier (Juni 2010)
Particle-lung cell interactions can be investigated in a triple cell culture in vitro model of the human airway wall. It is possible to analyze the cellular interplay and response of epithelial cells, human blood monocyte derived macrophages and dendritic cells after exposure to particles. More...
 

MACROPHAGES

3D model of human epithelial airway barrier (Juni 2010)
Particle-lung cell interactions can be investigated in a triple cell culture in vitro model of the human airway wall. It is possible to analyze the cellular interplay and response of epithelial cells, human blood monocyte derived macrophages and dendritic cells after exposure to particles. More...
 

BACTERIA

Quantitative, non-destructive biofilm analysis on irregular surfaces using microcalorimetry (Januar 2012)
This in-vitro approach allows the quantification of biofilm formation on implants, human bone grafts and bone-graft substitutes by means of microcalorimetry. The method has the advantage of allowing the detection of bacterial biomass without removing the biofilm from the surface of the specimen. More...
 


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