3R Research Foundation Switzerland - Front page

List of projects

Research Areas

ANALGESIA

71-00Detection and characterisation of signs of pain in mice by the combined use of a telemetry model and behavioural observations
Arras M., Dr., Institute of Laboratory Animal Science, University of Zürich, Switzerland
 

ANESTHESIA

ANIMAL WELFARE

122-10Improved perioperative analgesia and reduced stress during recovery for the experimental animal: ultrasound-guided sciatic and femoral nerve block in sheep and quantitative assessment of block quality
Rohrbach H., Dr, Institute for Anaesthesiology and Pain Therapy, Vetsuisse Faculty, University of Bern, Switzerland
 
88-03Assessing animal health and welfare and recognising pain and distress
Flecknell P., Prof. Dr., Comparative Biology Centre, University of Newcastle, UK
 

ANGIOGENESIS

139-14An in-vitro microvascular model of the endothelial barrier
Herrmann, M., Dr., AO Research Institute Davos, Switzerland
 
117-09Embryonic stem-cell-derived in-vitro model of tissue inflammation following confrontation with implant materials
Wartenberg M., Prof. Dr., Friedrich Schiller University Jena and Justus Liebig University Giessen, Germany
 
76-01Development of a model of heart angiogenesis in vitro
Battegay E., Prof. Dr., Outpatient Department of Internal Medicine and Department of Research, University Hospital Basel, Switzerland
 

BYPASS GRAFT STENOSIS

61-97An in vitro model to study mechanical forces on human venous coronary bypass graft stenosis: Molecular targeting by pharmacological intervention
Lüscher T. F., Prof. Dr., Cardiovascular Research, Institute of Physiology, University Zürich and Cardiology, University Hospital Zürich, Switzerland
 

CHEMICAL RISK ASSESSMENT

145-15Combining computational modelling with in-vitro cellular responses in order to predict chemical impact on fish growth
Schirmer, K., Prof. Dr., EAWAG, Swiss Federal Institute of Aquatic Science and Technology, Dübendorf, Switzerland
 

CNS, BRAIN DISORDERS

140-14Hydrocephalus simulator for testing of active ventriculoperitoneal shunts
Schmid Daners, M., Dr., Institute for Dynamic Systems and Control, Department of Mechanical and Process Engineering, ETH Zurich, Switzerland
 
93-04Development of a novel multicellular 3-dimensional blood brain barrier in vitro model
Ogunshola O., Dr., Institute of Veterinary Physiology, Vetsuisse Faculty, University of Zürich, Switzerland
 

COAGULATION

133-12Development of an in vitro system to grow and investigate vascular endothelial cells under physiological flow conditions
Rieben R., Prof., Department of Clinical Research, University of Bern, Switzerland
 
81-02In vitro model for the testing of endothelial cell activation and damage in whole blood
Rieben R., Prof. Dr., Heart Transplantation Laboratory, Cardiology, University Hospital Bern, Switzerland
 

COMPLEMENT SYSTEM

81-02In vitro model for the testing of endothelial cell activation and damage in whole blood
Rieben R., Prof. Dr., Heart Transplantation Laboratory, Cardiology, University Hospital Bern, Switzerland
 

CYTOKINES, GROWTH FACTORS

92-04Adjuvanticity of microbial-derived particles and synthetic analogs in vitro.
Padovan E., Prof. Dr., Instituto Gulbenkian de Ciência, Oerias, Portugal
 
60-97Transgenic protozoa (Trypanosoma spp.) as an alternative to transgenic animals
Roditi I., Prof. Dr., Institutes of General Microbiology and Parasitology, University of Bern, Switzerland
 
52-96Development of an interleukin-1 (IL-1) assay with rabbit blood as an alternative to the rabbit pyrogen test
Hartung T., Prof.. Dr., Biochemical Pharmacology, University of Konstanz, Germany
 
51-96Establishment of endotoxin limits in porcine vaccines: animal welfare aspects
Cussler K., Dr., Paul Ehrlich Institut, Langen, Germany
 
46-96Development and Validation of an In Vitro Model Simulating Mechanical Ventilation-Induced Inflammation
Pugin J., Dr., Division des Soins Intensifs de Médecine, Hôpital Cantonal Universitaire, Genève, Suisse
 

DRUG-DESIGN

75-00Internet laboratory for predicting harmful effects triggered by drugs and chemicals
Vedani A., Prof. Dr., Biographics Laboratory 3R, Basel, Switzerland present address: Department of Chemistry, Molecular Modeling. University of Basel, Pharmacenter, 4056 Basel, Switzerland
 
55-96Computer-aided identification of ochratoxin antagonists
Vedani A., Prof. Dr., Biographics Laboratory 3R, Basel, Switzerland
 

ECOTOXICOLOGY

123-10Use of "moribund" stage in the acute fish toxicity test according to OECD guideline 203 and its effect on LC50 values
Rufli H., Dr., ecotoxsolution, Basel, Switzerland
 
114-08Reduction of the number of animals used in the Fish Acute Toxicity Test
Rufli H., Dr., ecotoxsolution, Basel, Switzerland
 
108-07Cultured piscine hepatocytes as an in-vitro source of metabolic clearance data that is currently gleaned by in-vivo bioaccumulation testing in fish
Segner H., Prof. Dr., Centre for Fish and Wildlife Health, Vetsuisse Faculty, University of Berne, Switzerland
 
100-06Development of an in-vitro system for modeling bioaccumulation of neutral, ionizable, and metabolically active organic pollutants in fish
Escher B., Prof. Dr., Dept. of Environmental Toxicology, EAWAG, Dübendorf, Switzerland
 

ETHOLOGY

ETHOLOGY: LABORATORY ANIMALS

77-01Reproducibility and external validity of findings from animal experiments: influence of housing conditions
Würbel H., Prof. Dr., Institute of Laboratory Animal Science, University of Zurich, Switzerland
 
71-00Detection and characterisation of signs of pain in mice by the combined use of a telemetry model and behavioural observations
Arras M., Dr., Institute of Laboratory Animal Science, University of Zürich, Switzerland
 
66-99The influence of enriched housing conditions on experimental results in laboratory mice
Baumans V., Prof. Dr., Department of Laboratory Animal Science, University of Utrecht, Netherland
 
59-97Phenotype characterisation and health monitoring of transgenic mice
Mertens C., dipl. phil. nat., Zürcher Tierschutz (SPCA), Zürich, Switzerland
 
58-97Development of laboratory housing conditions preventing stereotypic behaviour in Mongolian gerbils (Meriones unguiculatus)
König B., Prof. Dr., Department of Animal Behaviour, Institute of Zoology, University of Zürich, Switzerland
 
57-97Laboratory animal husbandry and welfare - Key strategic goals of future research
Würbel H., Prof. Dr., Institute of Animal Sciences, Physiology and Animal Husbandry, Swiss Federal Institute of Technology (ETH), Switzerland
 

ETHOLOGY: TRANSGENIC ANIMALS

59-97Phenotype characterisation and health monitoring of transgenic mice
Mertens C., dipl. phil. nat., Zürcher Tierschutz (SPCA), Zürich, Switzerland
 

ETHOLOGY: ENRICHMENT

66-99The influence of enriched housing conditions on experimental results in laboratory mice
Baumans V., Prof. Dr., Department of Laboratory Animal Science, University of Utrecht, Netherland
 
58-97Development of laboratory housing conditions preventing stereotypic behaviour in Mongolian gerbils (Meriones unguiculatus)
König B., Prof. Dr., Department of Animal Behaviour, Institute of Zoology, University of Zürich, Switzerland
 

HEART VALVES

134-12Cardiovascular simulator with autoregulation
Vandenberghe S,, Prof., ARTORG Center for Biomedical Research, University of Bern, Switzerland
 

IMMUNOLOGY

137-13Validation of a new human in-vitro model of microglia
Filgueira, L., Prof., Department of Medicine, University of Fribourg, Switzerland
 
127-11Establishing a novel system for quantitative production of murine basophils in vitro
Kaufmann T., PD Dr., Institute of Pharmacology, University of Bern, Switzerland
 
101-06Organotypic CNS slice cultures as an in-vitro model for immune mediated tissue damage and repair in multiple sclerosis
Goebels N., Prof. Dr., Heinrich-Heine University Düsseldorf Medical Faculty, Department of Neurology
 
80-01Induction of a primary T cell mediated immune response against drugs and drug metabolites in vitro
Pichler, W.J., Prof. Dr., Division Allergology, University Hospital Bern, Switzerland
 

IMMUNOLOGY

IMMUNOLOGY: MONOCLONAL ANTIBODY PRODUCTION

56-96Development of a mimotope-based tetanus and diphtheria vaccine
Stadler B. M., Prof. Dr., Institute of Immunology and Allergology, Inselspital, University of Berne, Switzerland
 

IN VITRO TESTING

134-12Cardiovascular simulator with autoregulation
Vandenberghe S,, Prof., ARTORG Center for Biomedical Research, University of Bern, Switzerland
 

MECHANOBIOLOGY

130-11Establishment of an in-vitro organ-slice defect model for meniscal repair in orthopaedic research
Hunziker E., Prof., Center of Regenerative Medicine for Skeletal Tissues, University of Bern, Switzerland
 
122-10Improved perioperative analgesia and reduced stress during recovery for the experimental animal: ultrasound-guided sciatic and femoral nerve block in sheep and quantitative assessment of block quality
Rohrbach H., Dr, Institute for Anaesthesiology and Pain Therapy, Vetsuisse Faculty, University of Bern, Switzerland
 
83-02The development of an in vitro intervertebral disc organ culture system
Lee C., Dr., Biochemistry and Cell Biology Unit; AO Research Institute, Davos, Switzerland
 

NEUROLOGY

137-13Validation of a new human in-vitro model of microglia
Filgueira, L., Prof., Department of Medicine, University of Fribourg, Switzerland
 

ORTHOPEDICS

130-11Establishment of an in-vitro organ-slice defect model for meniscal repair in orthopaedic research
Hunziker E., Prof., Center of Regenerative Medicine for Skeletal Tissues, University of Bern, Switzerland
 
124-10Comparative in vitro and in vivo testing on biofilm formation on the surface of bone grafts
Clauss M., Dr., Kantonsspital Liestal, Orthopädie, Liestal, Switzerland
 
122-10Improved perioperative analgesia and reduced stress during recovery for the experimental animal: ultrasound-guided sciatic and femoral nerve block in sheep and quantitative assessment of block quality
Rohrbach H., Dr, Institute for Anaesthesiology and Pain Therapy, Vetsuisse Faculty, University of Bern, Switzerland
 

PHARMACOLOGY

93-04Development of a novel multicellular 3-dimensional blood brain barrier in vitro model
Ogunshola O., Dr., Institute of Veterinary Physiology, Vetsuisse Faculty, University of Zürich, Switzerland
 
91-04Establishment and validation of a Choroid Plexus Model to study drug transport
Fricker G., Prof. Dr., Institute of Pharmacy and Molecular Biotechnology, Ruprecht-Karls Universität Heidelberg, Germany
 
75-00Internet laboratory for predicting harmful effects triggered by drugs and chemicals
Vedani A., Prof. Dr., Biographics Laboratory 3R, Basel, Switzerland present address: Department of Chemistry, Molecular Modeling. University of Basel, Pharmacenter, 4056 Basel, Switzerland
 
69-99A human neural cell line as in vitro model system for the excitotoxic cascade during stroke
Bicker G., Prof. Dr., Abt. Zellbiologie, Physiologisches Institut, Stiftung Tierärztliche Hochschule Hannover, Germany
 
68-99Genetic analysis of a 3D in vitro model of the rheumatic pannus tissue
Illges H., PD Dr., Biotechnologie Institut Thurgau an der Universität Konstanz, Switzerland
 
55-96Computer-aided identification of ochratoxin antagonists
Vedani A., Prof. Dr., Biographics Laboratory 3R, Basel, Switzerland
 
54-96Elaboration of an in vitro screening method for testing the effect of drugs and other compounds on the renal transport of uric acid
Roch-Ramel F., Prof. Dr., Institute of Pharmacoly and Toxicology, University of Lausanne, Switzerland
 
53-96Axenic cultivation of amastigote forms of Leishmania
Grimm F., Dr. phil. nat., Institute of Parasitology, University of Zürich, Switzerland
 
50-96Morphometric Analysis of human articular cartilage
Hunziker E., Prof. Dr., M.E.Müller Institut für Biomechanik, University of Bern, Switzerland
 

PHAGOCYTOSIS

73-00Generation and functional characterization of a clonal murine periportal Kupffer cell line from H-2Kb -tsA58 mice
Landmann R., Prof. Dr., Division of Infectious Diseases, Department of Research, University Hospital Basel, Switzerland
 

PAIN / STRESS

122-10Improved perioperative analgesia and reduced stress during recovery for the experimental animal: ultrasound-guided sciatic and femoral nerve block in sheep and quantitative assessment of block quality
Rohrbach H., Dr, Institute for Anaesthesiology and Pain Therapy, Vetsuisse Faculty, University of Bern, Switzerland
 
96-05Assessment of pain and stress in mice by monitoring gene expression changes
Cinelli P., Dr., Institute of Laboratory Animal Science, University of Zurich, Switzerland
 

QSAR

95-05Development of QSAR-Models for Classification and Prediction of Baseline Toxicity and of Uncoupling of Energy Transduction
Spycher S. + Escher B., Prof. Dr., Dept. of Environmental Toxicology, EAWAG, Dübendorf, Switzerland
 
75-00Internet laboratory for predicting harmful effects triggered by drugs and chemicals
Vedani A., Prof. Dr., Biographics Laboratory 3R, Basel, Switzerland present address: Department of Chemistry, Molecular Modeling. University of Basel, Pharmacenter, 4056 Basel, Switzerland
 
55-96Computer-aided identification of ochratoxin antagonists
Vedani A., Prof. Dr., Biographics Laboratory 3R, Basel, Switzerland
 

VETERINARY DRUGS

105-06Establishment of an in vitro system for the prediction of the degree of virulence of classical swine fever virus isolates
Ruggli N., Dr., Institute of Virology and Immunoprophylaxis (IVI), Mittelhaeusern, Switzerland
 
85-03Development of an in vitro culture model to generate Neospora caninum and Toxoplasma gondii oocysts and sporozoites
Hemphill A., Prof. Dr., Institute of Parasitology, Faculty of Vetsuisse and of Medicine, University of Berne, Switzerland
 
79-01Screening methods for repellents and attachment deterrents for ticks in-vitro
Guerin P., PD Dr., Institute of Zoology, University of Neuchâtel, Switzerland
 
72-00Development and applications of an in vitro cultivation model for Neospora caninum tissue cyst formation
Hemphill A., Prof. Dr., Institute of Parasitology, Faculty of Vetsuisse and of Medicine, University of Berne, Switzerland
 

TUMOURIGENESIS

115-09Engineering of a human brain tumour model to replace animal experimentation
Preynat-Seauve O., Dr., University of Geneva, Switzerland
 
94-04Tumor targeted reporter gene expression to improve and refine traditional models of Tumor growth and metastasis
Vorburger S., Dr., Department of Clinical Research, Visceral and Transplantation Surgery, University Hospital Bern, Switzerland
 

TOXICOLOGY

138-13Optimization of the nerve-cell-mimicking liposome assay as an in-vitro alternative for the detection of Clostridium-botulinum neurotoxins and for a validation of their presence in complex sample materials
Avondet, M.-A., Toxinology Group, Spiez Laboratory, Switzerland
 
125-11Nerve-cell mimicking liposomes as in vitro alternative to potency-testing of toxins with multistep pathways, such as Botulinum neurotoxins
Weingart O.G., Dr., Institute for Food, Nutrition and Health (IFNH), ETH Zurich, Switzerland;
 
106-07Standardization and Pre-validation of MucilAir: A novel in vitro cell model of the human airway epithelium for testing acute and chronic effects of chemical compounds
Huang S., Dr., Epithelix Sàrl, Plan-les-Ouates, Geneva, Switzerland
 
95-05Development of QSAR-Models for Classification and Prediction of Baseline Toxicity and of Uncoupling of Energy Transduction
Spycher S. + Escher B., Prof. Dr., Dept. of Environmental Toxicology, EAWAG, Dübendorf, Switzerland
 
89-03In vitro replica of the inner surface of the lungs, for the study of particle-cell interaction
Geiser Kamber M., Prof. Dr., Institute of Anatomy, University of Bern, Switzerland
 
54-96Elaboration of an in vitro screening method for testing the effect of drugs and other compounds on the renal transport of uric acid
Roch-Ramel F., Prof. Dr., Institute of Pharmacoly and Toxicology, University of Lausanne, Switzerland
 
53-96Axenic cultivation of amastigote forms of Leishmania
Grimm F., Dr. phil. nat., Institute of Parasitology, University of Zürich, Switzerland
 
47-96Development of an in vitro system for the detection of estrogenic compounds (xenoestrogens)
Fent K., PD Dr., Swiss Federal Institute for Environmental Science and Technology (EAWAG), Switzerland
 
43-95Short term assay for liver cell activated neurotoxic drugs
Maier P., Prof. Dr., Institute of Toxicology, Swiss Federal Institute of Technology (ETH) and University of Zürich, Switzerland
 

TRANSPLANTATION

133-12Development of an in vitro system to grow and investigate vascular endothelial cells under physiological flow conditions
Rieben R., Prof., Department of Clinical Research, University of Bern, Switzerland
 
132-12Identification of predictive in vitro markers of hematopoietic stem cell function
Lutolf M. P., Prof., Institute of Bioengineering, Ecole Polytechnique Fédérale de Lausanne (EPFL), Lausanne, Switzerland
 
103-06An in vitro Model of Central Nervous System Infection and Regeneration: Neuronal Stem Cells as Targets of Brain Damage & Regenerative Therapies in Bacterial Meningitis.
Leib S.L., Prof. Dr., Institute of Infectious Diseases, University of Bern, Switzerland
 
102-06Isolated, autologous blood-perfused heart: Replacement of heterotopic heart transplantation
Bogdanova A, Dr., Institute of Veterinary Physiology, University of Zurich, Switzerland
 
81-02In vitro model for the testing of endothelial cell activation and damage in whole blood
Rieben R., Prof. Dr., Heart Transplantation Laboratory, Cardiology, University Hospital Bern, Switzerland
 

VACCINATION

136-13Development of an in-vitro potency assay for the Clostridium chauvoei vaccines: Replacement of the guinea-pig-challenge potency test
Frey, J., Prof., Institute of Veterinary Bacteriology, Vetsuisse Faculty, University of Bern, Switzerland
 
113-08Generic in-vitro evaluation assay for immunological correlates of protection to replace animal challenge infections
Summerfield A., Dr., Institute of Virology and Immunoprophylaxis (IVI), Mittelhaeusern, Switzerland
 
104-06Development of in vitro strategies to propagate and characterize hemotrophic mycoplasmas
Hofmann-Lehmann R., Prof. Dr., Clinical Laboratory, Vetsuisse-Faculty, University of Zurich, Switzerland
 
92-04Adjuvanticity of microbial-derived particles and synthetic analogs in vitro.
Padovan E., Prof. Dr., Instituto Gulbenkian de Ciência, Oerias, Portugal
 
85-03Development of an in vitro culture model to generate Neospora caninum and Toxoplasma gondii oocysts and sporozoites
Hemphill A., Prof. Dr., Institute of Parasitology, Faculty of Vetsuisse and of Medicine, University of Berne, Switzerland
 

VETERINARY DRUGS

105-06Establishment of an in vitro system for the prediction of the degree of virulence of classical swine fever virus isolates
Ruggli N., Dr., Institute of Virology and Immunoprophylaxis (IVI), Mittelhaeusern, Switzerland
 
85-03Development of an in vitro culture model to generate Neospora caninum and Toxoplasma gondii oocysts and sporozoites
Hemphill A., Prof. Dr., Institute of Parasitology, Faculty of Vetsuisse and of Medicine, University of Berne, Switzerland
 
79-01Screening methods for repellents and attachment deterrents for ticks in-vitro
Guerin P., PD Dr., Institute of Zoology, University of Neuchâtel, Switzerland
 
72-00Development and applications of an in vitro cultivation model for Neospora caninum tissue cyst formation
Hemphill A., Prof. Dr., Institute of Parasitology, Faculty of Vetsuisse and of Medicine, University of Berne, Switzerland